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Its GIP receptor binding is actually the most potent of the three pathways, with an EC50 of 0.0643 nM compared to 0.775 nM for GLP-1

Low weight polysaccharide of hericium erinaceus ameliorates colitis via inhibiting the NLRP3 inflammasome activation in association with gut microbiota modulation

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It should also be avoided by individuals with uncontrolled diabetes or blood sugar issues

Metabolism (2013) 62(11):154352.10.1016/j.metabol.2013.07.001 88 DaiYDaiDWangXDingZMehtaJL